You are here
Effect of YOCAS yoga on sleep, fatigue, and quality of life: A URCC CCOP randomized, controlled clinical trial among 410 cancer survivors.
Background: Impaired sleep quality (SQ) and fatigue are the most prevalent and troublesome side effects experienced by cancer survivors and both significantly impair quality of life (QOL). We conducted a nationwide, multi-site, phase II/III randomized, controlled, clinical trial examining the efficacy of yoga for improving SQ, fatigue and QOL among cancer survivors through the University of Rochester (UR) Cancer Center Community Clinical Oncology Program (CCOP) Research Base. Methods: Non-metastatic, cancer survivors suffering from moderate or greater sleep disruption between 2-24 months after completing adjuvant therapy with no participation in yoga during the previous 3 months were randomized into 2 arms: 1) standard care monitoring and 2) standard care plus the 4-week (wk) yoga intervention (2 x's/wk; 75 min./session). The yoga intervention utilized the UR Yoga for Cancer Survivors (YOCAS) program consisting of pranayama (breathing exercises), 18 gentle Hatha and Restorative yoga asanas (postures) and meditation. SQ, fatigue and QOL were assessed pre- and post-intervention. Results: 410 survivors were accrued (96% female, mean age = 54, 75% breast cancer). ANCOVAs with baseline values as covariates revealed significant differences in SQ, fatigue and QOL (all p<0.05) between groups at post- intervention. Yoga participants demonstrated greater improvements in SQ (CS=change score; CS=1.96, standard error=SE; SE=0.25), fatigue (CS=7.82, SE=1.06) and QOL (CS=6.61, SE=1.11) from pre- to post-intervention compared to controls (SQ CS=1.07, SE=0.23, fatigue CS=2.34, SE=0.91 and QOL CS=1.58, SE=1.09). ANCOVAs also revealed the yoga group reduced sleep medication use (CS=-0.21, SE=0.09, p<0.05) while the control group increased medication use (CS=0.04, SE=0.07, p=0.09). Conclusions: The brief community-based YOCAS yoga intervention significantly improves SQ, fatigue, and QOL while reducing sleep medication use among survivors. Clinicians should consider prescribing the YOCAS program for survivors reporting impaired sleep and fatigue. Funding: NCI U10CA37420 and K07CA120025.
Abstracts by K. M. Mustian:
Exercise for cancer-related fatigue and putative functional, inflammatory, and metabolic mechanisms in patients receiving chemotherapy: A URCC CCOP research base phase III RCT.Meeting: 2013 ASCO Annual Meeting | Abstract No: TPS9651
Cognitive difficulties among patients with cancer receiving chemotherapy affects quality of life: A University of Rochester Clinical Community Oncology Program study of 439 patients.Meeting: 2011 ASCO Annual Meeting | Abstract No: 9119
Effect of YOCAS yoga on circadian rhythm, anxiety, and mood: A URCC CCOP randomized, controlled clinical trial among 410 cancer survivors.Meeting: 2011 ASCO Annual Meeting | Abstract No: 9034