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Standardized, progressive exercise program (EXCAP) to reduce psychological distress and improve inflammatory cytokines of distress among prostate cancer survivors.
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^).
Background: Psychological distress (a negative emotional, social, or spiritual response to cancer) is among the most common side effects of cancer diagnosis and treatment. Brief and palatable interventions are needed to ameliorate distress in diverse cancer populations, including men with prostate cancer, who may be unwilling to engage in traditional and time-intensive forms of psychotherapy. EXCAP(Exercise for Cancer Patients), a standardized, 6-week, home-based, progressive aerobic and resistance training program, has proven efficacious in improving fatigue among cancer survivors, but its effect on distress and on inflammatory cytokines associated with the pathophysiology of distress are unknown. Methods: In this Phase II RCT, 58 older prostate cancer survivors (age M=67) were randomized either to Arm 1) standard care (control) or Arm 2) EXCAP(intervention). Psychological distress (from the Profile of Mood States) and inflammatory cytokines (IFN-γ, IL-6, IL-8, IL-10, sTNFR-1) were measured at baseline and post-intervention (6 wks later). We used ANCOVA to assess the effect of EXCAPon distress and inflammatory cytokines at post-intervention, controlling for baseline values. We used Pearson correlations to evaluate mechanistic associations between change in distress and change in inflammatory cytokines from pre to post. Results: Among men with prostate cancer, the EXCAPintervention significantly improved psychological distress relative to standard care, as measured by the POMS Total score (EXCAP M=-5.17, SD=14.02; control M=2.43, SD=8.06; F(4,51)=3.34, p=.02). Decreases in distress among EXCAPparticipants were associated with decreases in IFN-γ (r = .40, p = .03) and IL-10 (r = .39, p = .04). This pattern was not seen in the control arm. Conclusions: This study supports the use of EXCAPfor reducing psychological distress and suggests a potential biological mechanism by which this improvement occurs, namely by reducing systemic inflammation. Future, confirmatory research is needed to replicate these findings in larger and diverse samples of cancer survivors. Clinical trial information: NCT00815672.
Abstracts by Charles Stewart Kamen:
A URCC NCORP nationwide randomized controlled trial investigating the effect of exercise on chemotherapy-induced peripheral neuropathy in 314 cancer patients.Meeting: 2016 ASCO Annual Meeting | Abstract No: 10000
Dyadic exercise to reduce depression and associated inflammatory cytokines among lesbian, gay, and heterosexual cancer survivors.Meeting: 2016 ASCO Annual Meeting | Abstract No: 10069
Ethnic/racial and socioeconomic disparities as predictors of behavioral risk factors among 7559 cancer survivors.Meeting: 2016 ASCO Annual Meeting | Abstract No: 6550
Presentations by Charles Stewart Kamen:
Standardized, progressive exercise program (EXCAP) to reduce psychological distress and improve inflammatory cytokines of distress among prostate cancer survivors.Meeting: 2014 ASCO Annual Meeting Abstract No: 9510Session: Outcomes and Interventions in Older Cancer Patients and Survivors (Clinical Science Symposium)