You are here
A multicenter yearlong randomized controlled trial of different exercise modalities in prostate cancer survivors on androgen deprivation therapy.
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^).
Background: It is well recognized that androgen deprivation therapy (ADT) for prostate cancer is associated with a number of substantial adverse effects including a reduction in muscle mass and strength, increased fat mass and poorer physical function. Recently, undertaking purposeful physical exercise has been proposed as an effective strategy to counter many of these ADT-related adverse effects. The purpose of this multi-centre, year-long randomized controlled trial was to extend these findings by assessing the effects of two varying exercise regimens, one targeting the musculoskeletal system (impact loading + resistance training; ILRT) and the other the cardiovascular and muscular systems (aerobic + resistance training; ART), on body composition, lower body muscle strength and physical function in men currently undertaking ADT. Methods: One hundred and sixty three men aged 42-90 years with a BMI of 24.8 kg/m2 completed baseline testing and were randomized to ILRT (n=58), ART (n=54) or delayed exercise (CON, n=51) for 12 months. Training was undertaken for ~1 hour twice weekly under supervision at a moderate-to-high intensity. Lean and fat mass were determined by DXA, muscle strength by the 1-RM test, and lower body physical function by a battery of tests (6-m walk, 6-m backwards walk, 400-m walk, chair rise, stair climb). Results: There were no differences among the groups for any variable at baseline. Between pre and post-intervention, lean mass increased in ILRT by 1.4 kg (p<0.001) and 0.6 kg (p=0.030) in ART with no change in CON. Fat mass also increased in ILRT and CON by1.1 kg (p<0.001) with no significant change in ART (0.6 kg, p=0.156). Upper and lower body muscle strength increased by 17-45% in ILRT which was greater than that in ART and CON (p<0.001). Compared to pre-intervention, ILRT and ART generally improved in most physical function tasks (p<0.050). Conclusions: The combination of impact loading and resistance training produced superior gains in lean mass and muscle strength compared to aerobic plus resistance exercise in prostate cancer survivors on ADT. Strategies to implement this novel training protocol are warranted. Clinical trial information: ACTRN12609000200280.
Abstracts by Daniel Abido Galvao:
Australian prostate cancer survivors? compliance to contemporary aerobic and resistance exercise oncology guidelines and associations with psychological distress, unmet supportive care needs and quality of life.Meeting: 2015 ASCO Annual Meeting | Abstract No: e16089
Meeting: 2014 ASCO Annual Meeting
| Abstract No: 9533
Category: Patient and Survivor Care - Survivorship