A multicenter yearlong randomized controlled trial of different exercise modalities in prostate cancer survivors on androgen deprivation therapy.

Genitourinary (Prostate) Cancer
Session Type and Session Title: 
Poster Highlights Session, Genitourinary (Prostate) Cancer
Abstract Number: 
J Clin Oncol 32:5s, 2014 (suppl; abstr 5037)
Daniel Abido Galvao, Dennis R Taaffe, Prue Cormie, Nigel Spry, David John Joseph, Suzanne K Chambers, Robert Alexander Gardiner, Kate Bolam, Bradley Alan Wall, Robert Usher Newton; Edith Cowan University, Perth, Australia; University of Newcastle, Ourimbah, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Griffith Health Institute, Brisbane, Australia; University of Queensland Centre for Clinical Research, Brisbane, Australia; School of Human Movement Studies, The University of Queensland, Brisbane, Australia; Murdoch University, Perth, Australia

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Abstract Disclosures


Background: It is well recognized that androgen deprivation therapy (ADT) for prostate cancer is associated with a number of substantial adverse effects including a reduction in muscle mass and strength, increased fat mass and poorer physical function. Recently, undertaking purposeful physical exercise has been proposed as an effective strategy to counter many of these ADT-related adverse effects. The purpose of this multi-centre, year-long randomized controlled trial was to extend these findings by assessing the effects of two varying exercise regimens, one targeting the musculoskeletal system (impact loading + resistance training; ILRT) and the other the cardiovascular and muscular systems (aerobic + resistance training; ART), on body composition, lower body muscle strength and physical function in men currently undertaking ADT. Methods: One hundred and sixty three men aged 42-90 years with a BMI of 24.8 kg/m2 completed baseline testing and were randomized to ILRT (n=58), ART (n=54) or delayed exercise (CON, n=51) for 12 months. Training was undertaken for ~1 hour twice weekly under supervision at a moderate-to-high intensity. Lean and fat mass were determined by DXA, muscle strength by the 1-RM test, and lower body physical function by a battery of tests (6-m walk, 6-m backwards walk, 400-m walk, chair rise, stair climb). Results: There were no differences among the groups for any variable at baseline. Between pre and post-intervention, lean mass increased in ILRT by 1.4 kg (p<0.001) and 0.6 kg (p=0.030) in ART with no change in CON. Fat mass also increased in ILRT and CON by1.1 kg (p<0.001) with no significant change in ART (0.6 kg, p=0.156). Upper and lower body muscle strength increased by 17-45% in ILRT which was greater than that in ART and CON (p<0.001). Compared to pre-intervention, ILRT and ART generally improved in most physical function tasks (p<0.050). Conclusions: The combination of impact loading and resistance training produced superior gains in lean mass and muscle strength compared to aerobic plus resistance exercise in prostate cancer survivors on ADT. Strategies to implement this novel training protocol are warranted. Clinical trial information: ACTRN12609000200280.