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The impact treatment has on cardiovascular risks factors for breast cancer survivors.
General Session VIII: Poster Discussion B
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^).
Background: The Integrative Health and Wellness center at VM Medical was established to monitor the body composition, activity level and vital signs of both the regular patients and the cancer survivors during their annual mammography screening. To determine if body composition and basic cardiovascular function of cancer survivors may vary depending on the type of adjuvant therapy dispensed. Methods: Kinesiologists performed base line measurements on 4,414 patient at The VM Medical Breast Center. Measurements were obtained on 3,674 non-oncology female patients and 740 cancer survivors. The data included BMI, resting heart rate, blood pressure, total body fat, lean muscle and waist circumference. The cancer survivors were stratified into 8 different groups (G1-G8) according to the type of surgery they underwent and compared to the regular patients(R). A one way ANOVA was performed with Dunnet post hoc analysis, significance was set at p < 0.05. The two largest groups were; women who underwent surgery, chemotherapy, radiotherapy and hormone therapy (G5) 243 patients, as part of their treatment and women who underwent surgery, radiotherapy and hormone therapy (G6) 207 patients, as part of their treatment. The other 290 patients were separated into the other 6 treatment groups. Results: Significant differences were seen between the cancer survivors in all groups and the regular patients with p= 0.00 in 7 key variables. BMI(F=4.30) µ= 26.08 (R) vs µ= 27.10 (G6), resting heart rate (F= 6.24) µ= 73.04 bts/min (R) vs µ= 76.45 bts/min (G5), diastolic blood pressure (F= 4.65) µ= 74.18 mmHg (R) vs µ= 77.00 mmHg (G5), systolic blood pressure (F= 8.75) µ= 123.04 mmHg (R) vs µ= 130.14 mmHg (G6), lean muscle (F= 3.48) µ= 10.09 kgs (R) vs µ= 9.74 kgs (G6), total body fat (F=9.02) µ= 34.45% (R) vs µ= 37.49% (G6) and waist circumference (F= 4.44) µ= 84.91 cm (R) vs µ= 87.68 cm (G5). Conclusions: It would appear that different treatment protocols are associated with an increase in negative body composition and blood pressure measurements in cancer survivors. This information is important for the medical team to consider when directing the cancer survivors on healthy lifestyle choices post treatment.
Abstracts by John R. Keyserlingk:
Phase III, randomized, double-blind, placebo-controlled study of ribociclib (LEE011) in combination with either tamoxifen and goserelin or a non-steroidal aromatase inhibitor (NSAI) and goserelin for the treatment of premenopausal women with HR+, HER2– advanced breast cancer (aBC): MONALEESA-7.Meeting: 2015 ASCO Annual Meeting | Abstract No: TPS625Category: Breast Cancer—HER2/ER - ER+
Does the side of surgery and treatment have an effect on cardiovascular measurements in breast cancer survivors?Meeting: 2014 ASCO Annual Meeting | Abstract No: e17674